Zinc is the second most common natural trace element in the body, protecting against oxidative stress and DNA damage. Around 2 billion people worldwide have zinc deficient diets. Animal models show how zinc deficiency associated with aging may lead to zinc transporter dysregulation, resulting in decreased cellular zinc levels and enhanced inflammatory responses. Restoring zinc status via supplementation reduced age-associated inflammation.
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Carmen P. Wong, Kathy R. Magnusson, Emily Ho. Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. The Journal of Nutritional Biochemistry, 2012